Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD
St. John's Wort
MODERATE EVIDENCEBotanicalLast updated
AVELOR SUMMARY
Hypericum perforatum — equivalent to SSRIs for mild-moderate depression (Linde 2008 Cochrane review). CRITICAL DRUG INTERACTIONS: PXR/CYP3A4 induction reduces effectiveness of OCPs, warfarin, HIV drugs, immunosuppressants, many more. The most dangerous herb for drug interactions in the entire supplement industry.
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*Reviewed by the Dose AI Research Team and Clinical Advisory Board*
*Last updated: 2026-04-06*
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.