Quercetin Phytosome

Quercefit® (Indena) is quercetin complexed with sunflower lecithin in a 1:1 weight ratio. In a randomized crossover pharmacokinetic trial in 12 healthy volunteers, a 500mg dose reached a peak plasma quercetin concentration of 223 ng/mL, about 20-fold higher than the same 500mg dose of unformulated quercetin, with total exposure (AUC) about 18-fold larger (Riva 2019, PMID: 30328058). An independent 2025 systematic review of 31 human intervention studies put the lecithin phytosome increase at 20.1-fold relative to quercetin aglycone (Liu 2025, PMID: 40037045). The practical consequence is that the plasma quercetin levels used in human trials are reached at modest daily doses. for mechanism details.