Is Evodiamine safe to take daily?

Evodiamine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Evodiamine

Creator: Avelor Research Team
Published: 2026-04-01

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Evodiamine is a thermogenic compound from the Chinese herb Evodia that activates TRPV1 (vanilloid receptor, same as capsaicin) to increase core body temperature and energy expenditure. In vitro data shows fat cell apoptosis and anti-obesity effects. ZERO human clinical trials exist. Sold in fat-burner supplements but no established human dose. Our assessment: promising mechanism, zero human evidence. --- *Reviewed by the Avelor Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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