Is Ashitaba safe to take daily?

Ashitaba is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Ashitaba

Creator: Avelor Research Team
Published: 2026-04-01

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Japanese longevity herb from Hachijō Island. Contains 4,4'-dimethoxychalcone (DMC), the compound identified in a 2019 Nature Medicine paper as activating autophagy and extending lifespan in yeast, worms, and flies. DMC is the ONLY chalcone shown to activate TFEB (transcription factor EB, master regulator of autophagy). Also contains prenylated chalcones with anti-inflammatory and anti-diabetic activity. Limited human data but the autophagy mechanism is validated in multiple model organisms. Dose: 500-1,500mg/day dried leaf/stem. --- *Reviewed by the Avelor Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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