Shilajit's primary active compound is fulvic acid, a humic substance that acts as an electron shuttle in mitochondria, enhancing the efficiency of the electron transport chain (complexes I-IV). This means cells produce more ATP per unit of oxygen consumed. For testosterone, the proposed mechanism involves: (1) protection of Leydig cells from oxidative damage via fulvic acid's antioxidant activity; (2) enhanced hypothalamic-pituitary-gonadal signaling; (3) increased 17β-hydroxysteroid dehydrogenase activity (the enzyme that converts androstenedione to testosterone). Dibenzo-alpha-pyrones contribute to the CoQ10-enhancing effect.
Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.