What is the recommended dose of Manganese?

- **Look for:** Most people do NOT need manganese supplements, dietary intake is almost always sufficient. If in a multivitamin, 1-2mg is appropriate. - **Avoid:** Standalone manganese supplements ...

Ingredient Research

Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Manganese

MineralLast updated

AVELOR SUMMARY

Manganese is a trace mineral essential for antioxidant defense (MnSOD), bone formation, and glucose metabolism. Our research highlights a critical paradox: deficiency is extremely rare (manganese is abundant in plant foods), but EXCESS is neurotoxic, causing a Parkinson's-like condition called manganism. Welders and miners get it from occupational inhalation. The UL is 11mg/day, but neurotoxicity symptoms have been reported at chronic intakes of 4-15mg/day from supplements in susceptible individuals. This is a mineral where supplementation is rarely justified and potentially dangerous.

WHAT IT DOES

Manganese is a cofactor for: (1) MnSOD, the superoxide dismutase that protects mitochondria from oxidative damage; (2) arginase, needed for urea cycle (ammonia detoxification); (3) pyruvate carboxylase, gluconeogenesis; and (4) glycosyltransferases, proteoglycan synthesis for bone and cartilage. The neurotoxicity of excess manganese occurs because it accumulates preferentially in the globus pallidus (basal ganglia), where it disrupts dopaminergic neurotransmission, the same pathway affected in Parkinson's disease.

OPTIMAL DOSAGE

Look for: Most people do NOT need manganese supplements, dietary intake is almost always sufficient. If in a multivitamin, 1-2mg is appropriate.
Avoid: Standalone manganese supplements >5mg/day; products marketing manganese as a primary ingredient; colloidal manganese
Minimum effective dose: Rarely needed as supplement. If included in multi: 1-2mg is safe.
Third-party tested brands: Standard multivitamins include appropriate amounts

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Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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