Yerba mate contains: (1) caffeine (1-1.5% by weight), adenosine receptor antagonism, catecholamine release, thermogenesis; (2) theobromine, mild bronchodilator and mood elevator (same compound as in chocolate); (3) chlorogenic acids, inhibit hepatic glucose-6-phosphatase (reduce glucose output) and intestinal α-glucosidase (slow sugar absorption); (4) saponins (matesaponins), inhibit pancreatic lipase (reduce fat absorption) and have anti-inflammatory/antimicrobial activity; (5) polyphenols, antioxidant and NF-κB inhibition. The fat oxidation enhancement during exercise is likely synergistic between caffeine (catecholamine-driven lipolysis) and chlorogenic acid (fatty acid oxidation enhancement).
Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.