What is the recommended dose of Turkey Tail Mushroom?

- **PSK (Krestin):** 3,000mg/day (Japanese cancer adjunct dose) - **PSP (polysaccharopeptide):** 1,000-3,000mg/day - **Generic turkey tail extract:** 1,000-3,000mg/day - **Duration:** Long-term use...

Does Turkey Tail Mushroom interact with any medications?

Turkey Tail Mushroom lists 3 reported drug interactions whose sources are not yet verified, including interactions with Immunosuppressants, Chemotherapy, Diabetes medications. Check with your doctor before combining with prescription medications.

Ingredient Research

Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Turkey Tail Mushroom

SupplementLast updated April 2026

AVELOR SUMMARY

Turkey tail is the most studied medicinal mushroom for immune support, with two specific polysaccharide extracts (PSK and PSP) showing evidence as cancer adjunct therapy, particularly in colorectal and gastric cancers. Our research distinguishes it from immune-supportive mushrooms like reishi: turkey tail has actual phase II/III cancer trial data from Japanese and Chinese oncology.

EVIDENCE GRADES

Immune modulation (NK cell, T-cell activation)

Moderate evidenceGrade B

Gut microbiomePrebiotic effects documented

Limited evidenceGrade C+

General immune supportBased on polysaccharide immunomodulation

Limited evidenceGrade C+

OPTIMAL DOSAGE

PSK (Krestin): 3,000mg/day (Japanese cancer adjunct dose)
PSP (polysaccharopeptide): 1,000-3,000mg/day
Generic turkey tail extract: 1,000-3,000mg/day
Duration: Long-term use in cancer adjunct trials (months to years)

Scan a supplement containing Turkey Tail Mushroom

DRUG INTERACTIONS

Immunosuppressants

Immunostimulatory, opposes immunosuppression

Chemotherapy

Used AS adjunct to chemo in trials, may enhance efficacy but always inform oncologist

Diabetes medications

May lower blood sugar

SAFETY PROFILE

Side Effects

GI effects: gas, bloating (polysaccharide fermentation)
Darkening of fingernails (documented with PSK, harmless)
Generally very well tolerated

Pregnancy & Lactation

Insufficient data. Not recommended during pregnancy.

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

PSK and PSP extracts score highest (most clinical data)

Generic "turkey tail" powder without polysaccharide standardization: lower confidence

Beta-glucan content should be declared

Immunosuppressant users: automatic severe interaction flag

Cancer patients: note as one of the few mushrooms with actual oncology trial data, but ALWAYS recommend oncologist consultation

Mycelium-on-grain products: flag same concern as lion's mane (starch contamination)

CLINICAL REFERENCES

Reference identifiers on this page are being re-verified against PubMed. Some may not yet link to the paper named beside them.

, Torkelson CJ et al. Phase 1 clinical trial of Trametes versicolor in women with breast cancer.

PMID: 25006989

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Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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Ingredient Research

Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Turkey Tail Mushroom

SupplementLast updated April 2026

AVELOR SUMMARY

EVIDENCE GRADES

Immune modulation (NK cell, T-cell activation)

Moderate evidenceGrade B

Gut microbiomePrebiotic effects documented

Limited evidenceGrade C+

General immune supportBased on polysaccharide immunomodulation

Limited evidenceGrade C+

OPTIMAL DOSAGE

PSK (Krestin): 3,000mg/day (Japanese cancer adjunct dose)
PSP (polysaccharopeptide): 1,000-3,000mg/day
Generic turkey tail extract: 1,000-3,000mg/day
Duration: Long-term use in cancer adjunct trials (months to years)

Scan a supplement containing Turkey Tail Mushroom

DRUG INTERACTIONS

Immunosuppressants

Immunostimulatory, opposes immunosuppression

Chemotherapy

Used AS adjunct to chemo in trials, may enhance efficacy but always inform oncologist

Diabetes medications

May lower blood sugar

SAFETY PROFILE

Side Effects

GI effects: gas, bloating (polysaccharide fermentation)
Darkening of fingernails (documented with PSK, harmless)
Generally very well tolerated

Pregnancy & Lactation

Insufficient data. Not recommended during pregnancy.

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

PSK and PSP extracts score highest (most clinical data)

Generic "turkey tail" powder without polysaccharide standardization: lower confidence

Beta-glucan content should be declared

Immunosuppressant users: automatic severe interaction flag

Cancer patients: note as one of the few mushrooms with actual oncology trial data, but ALWAYS recommend oncologist consultation

Mycelium-on-grain products: flag same concern as lion's mane (starch contamination)

CLINICAL REFERENCES

Reference identifiers on this page are being re-verified against PubMed. Some may not yet link to the paper named beside them.

, Torkelson CJ et al. Phase 1 clinical trial of Trametes versicolor in women with breast cancer.

PMID: 25006989

RELATED RESEARCH

Acacia Fiber

AcarboseANIMAL ONLY. In the NIA Interventions Testing Program, a parallel three-site study in genetically he

Activated Charcoal

Agave Inulin

Scan Your Turkey Tail Mushroom Supplement Browse all ingredients

Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 772 Ingredients Browse All 20 Conditions