Shiitake contains lentinan (beta-glucan approved as anti-cancer adjunct in Japan), eritadenine (cholesterol-reducer, inhibits ACAT, reducing cholesterol absorption by 25%), and L-ergothioneine (rare amino acid antioxidant).
Lentinan injection is Japanese-approved for gastric cancer (extends survival when combined with chemo).
Oral shiitake extract: 5-10g/day improves immune markers (increased IgA, improved T-cell function). Eritadenine is unique to shiitake, no other food source.
CAUTION: raw shiitake can cause flagellate dermatitis (itchy rash from lentinan in uncooked mushrooms, cook thoroughly).
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*Reviewed by the Avelor Research Team and Clinical Advisory Board*
*Last updated: 2026-04-06*