Is Paw Paw safe to take daily?

Paw Paw is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Paw Paw

Creator: Avelor Research Team
Published: 2026-04-01

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

North American paw paw (NOT papaya) contains acetogenins, compounds that inhibit mitochondrial Complex I in cancer cells. Related to Graviola (Annona muricata). The anticancer mechanism is validated in vitro but ZERO human clinical trials exist. Acetogenins are also neurotoxic at high doses, epidemiological link to atypical parkinsonism in Caribbean populations consuming large quantities of Annona species. Our assessment: anti-cancer mechanism real, human evidence absent, neurotoxicity concern. --- *Reviewed by the Avelor Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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