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Myo-inositol is a second messenger in the insulin signaling cascade. After insulin binds its receptor, a phospholipase cleaves phosphatidylinositol → inositol phosphoglycans (IPGs) → which activate downstream insulin signals (GLUT4 translocation, glycogen synthesis). In PCOS, this pathway is impaired, excess insulin is produced to compensate (hyperinsulinemia), which stimulates ovarian androgen production (testosterone, causing acne, hirsutism, anovulation). Supplemental myo-inositol restores insulin sensitivity → reduces compensatory hyperinsulinemia → reduces ovarian androgen production → restores ovulation. For anxiety: myo-inositol is the precursor to phosphatidylinositol, which is required for serotonin receptor (5-HT2) signaling, explaining the anti-anxiety effect at high doses.
No critical interactions identified.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.