Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD
HMB
MODERATE EVIDENCEAmino AcidLast updated
AVELOR SUMMARY
Beta-hydroxy beta-methylbutyrate — leucine metabolite. 3g/day reduces muscle protein breakdown during caloric deficit, illness, or injury. Most useful for PREVENTING catabolism (elderly, hospital, cutting), NOT for building muscle in healthy trained individuals. The Wilson 2014 study showing 7.4kg lean mass gain was never replicated and widely criticized.
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*Reviewed by the Dose AI Research Team and Clinical Advisory Board*
*Last updated: 2026-04-06*
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.