What is the recommended dose of Hesperidin?

- **Look for:** G-hesperidin (glucosyl form, best absorption); micronized hesperidin; Daflon® 500mg (for venous insufficiency); 250-500mg per serving - **Avoid:** Non-micronized hesperidin powder (...

Is Hesperidin safe to take daily?

Hesperidin is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Hesperidin

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Hesperidin is the dominant flavonoid in oranges and citrus peel, a single glass of orange juice contains 30-60mg. Our research shows it has well-documented vascular effects: a 2011 RCT found 292mg/day reduced diastolic blood pressure by 3 mmHg and improved endothelial function (flow-mediated dilation) by 25%. It's one of the active compounds behind "an orange a day keeps the doctor away." The glucosyl form (G-hesperidin) is water-soluble and 3x more bioavailable than standard hesperidin. Often combined with diosmin for chronic venous insufficiency (the Daflon® 500mg combination is the most prescribed venoactive drug in Europe).

WHAT IT DOES

Hesperidin and its aglycone hesperetin work through: (1) increasing endothelial NO synthase (eNOS) activity and NO bioavailability, improving vasodilation and reducing blood pressure; (2) inhibiting phosphodiesterase (PDE) in venous smooth muscle, increasing cAMP, which improves venous tone and reduces stasis; (3) reducing capillary permeability by strengthening inter-endothelial junctions; (4) inhibiting NF-κB and ICAM-1, reducing vascular inflammation and leukocyte adhesion. In the gut, hesperidin is converted by intestinal bacteria to hesperetin, which is then absorbed, meaning gut microbiome composition affects bioavailability.

OPTIMAL DOSAGE

Look for: G-hesperidin (glucosyl form, best absorption); micronized hesperidin; Daflon® 500mg (for venous insufficiency); 250-500mg per serving
Avoid: Non-micronized hesperidin powder (nearly insoluble); "citrus bioflavonoids" without hesperidin quantification
Minimum effective dose: 250mg/day hesperidin
Third-party tested brands: Daflon (Servier, prescription in EU, supplement in US), NOW Foods (Citrus Bioflavonoids), Life Extension

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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