Chlorogenic acid (CGA), a polyphenol ester of caffeic acid and quinic acid, works through: (1) inhibition of glucose-6-phosphatase in the liver, reducing gluconeogenesis and hepatic glucose output; (2) inhibition of intestinal α-glucosidase, slowing carbohydrate digestion and glucose absorption; (3) NO-mediated vasodilation (similar to other polyphenols), lowering blood pressure; (4) AMPK activation, stimulating fatty acid oxidation. Roasting coffee at >200°C destroys 80-100% of CGA, which is why green (unroasted) beans are used. However, the fat-burning effects are modest at best, the dramatic results were fabricated.
No critical interactions identified.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.