What is the recommended dose of Glutathione?

- **Oral glutathione:** 250-1,000mg/day (bioavailability questionable) - **Liposomal glutathione:** 250-500mg/day (better absorption) - **Better approach:** NAC (600-1,800mg/day) as glutathione pre...

Is Glutathione safe to take daily?

Glutathione is rated "Generally Safe" based on clinical evidence. - Generally well tolerated at typical doses - GI symptoms possible

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Glutathione

MODERATE EVIDENCESupplementLast updated April 5, 2026

AVELOR SUMMARY

Glutathione is your body's master antioxidant — a tripeptide (glutamate, cysteine, glycine) present in every cell. Here's the problem: oral glutathione is poorly absorbed. Your stomach breaks it down before it reaches your bloodstream. Most research suggests supplementing with glutathione precursors (NAC, glycine + cysteine) is more effective than taking glutathione directly. Liposomal and sublingual forms may improve absorption somewhat.

OPTIMAL DOSAGE

Oral glutathione: 250-1,000mg/day (bioavailability questionable)
Liposomal glutathione: 250-500mg/day (better absorption)
Better approach: NAC (600-1,800mg/day) as glutathione precursor
Or: Glycine (2g) + NAC (600mg) combination ("GlyNAC" protocol)

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SAFETY PROFILE

Side Effects

Generally well tolerated at typical doses
GI symptoms possible

Drug Interactions

No significant drug interactions documented for oral glutathione
May theoretically reduce effectiveness of chemotherapy drugs (antioxidant interference)

Precautions

Pregnancy/Breastfeeding: Insufficient data. Glutathione is naturally produced in the body.
Cancer patients: Discuss with oncologist — antioxidants may theoretically interfere with some chemo mechanisms.

WADA Status

Not Prohibited.

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

Present at 250-1,000mg (liposomal form):⚠️ Yellow flag — limited evidence for oral supplementation efficacy

Present in standard oral form:⚠️ Yellow flag — poor bioavailability, likely ineffective

NAC as precursor instead:✅ Green flag — better evidence-backed approach

Marketed as "master antioxidant" without addressing bioavailability:⚠️ Yellow flag — misleading if not liposomal/sublingual

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 5, 2026

Not medical advice. Based on published clinical research and systematic reviews.

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