Is DGL safe to take daily?

DGL is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

DGL

Creator: Avelor Research Team
Published: 2026-04-01

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

DGL is licorice root with glycyrrhizin REMOVED, eliminating the compound that causes hypertension and hypokalemia. What remains: flavonoids and saponins that increase gastric mucin production and prostaglandin E2, protecting the stomach lining. A 1978 study found DGL was as effective as cimetidine (Tagamet) for gastric ulcer healing. Must be CHEWED (not swallowed), the flavonoids mix with saliva and contact the esophageal/gastric mucosa directly. GutGard® is a standardized DGL with clinical data. Dose: 380-760mg chewed 20 minutes before meals. --- *Reviewed by the Avelor Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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