What is the recommended dose of D-Aspartic Acid?

- **Most studied:** 2,000-3,000mg/day (sodium D-aspartate form) - **Fertility applications:** 2,660mg/day for 90 days - **Cycle:** Most protocols suggest 2-3 weeks on, 1-2 weeks off

Is D-Aspartic Acid safe to take daily?

D-Aspartic Acid is rated "Generally Safe" based on clinical evidence. - Irritability and mood changes (anecdotal) - Headache (uncommon) - GI discomfort

Does D-Aspartic Acid interact with any medications?

D-Aspartic Acid has 1 known drug interaction, including interactions with Testosterone replacement therapy. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

D-Aspartic Acid

LIMITED EVIDENCESupplementLast updated April 2026

AVELOR SUMMARY

D-Aspartic acid was briefly hyped as a natural testosterone booster, our research shows the initial positive study has NOT been replicated in young, healthy men. One trial showed 15% testosterone increase over 12 days in untrained men, but subsequent trials in resistance-trained men found no effect or even slight decreases. The evidence does not support DAA for testosterone boosting in athletic populations.

EVIDENCE GRADES

Testosterone increase (untrained/older men)One positive trial, not replicated (PMID: 19860889)

Testosterone (resistance-trained men)Null or negative results (UNCITED: the cited PMID did not support this claim and was removed; this statement is not currently sourced)

Male fertility (sperm quality)More promising, improved sperm parameters

C+

Luteinizing hormoneAcute increase, uncertain chronic effect

OPTIMAL DOSAGE

Most studied: 2,000-3,000mg/day (sodium D-aspartate form)
Fertility applications: 2,660mg/day for 90 days
Cycle: Most protocols suggest 2-3 weeks on, 1-2 weeks off

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DRUG INTERACTIONS

Testosterone replacement therapyMinor

May have additive effects on LH/FSH axis; clinically irrelevant if on exogenous T

SAFETY PROFILE

Drug Interactions

Side Effects

Irritability and mood changes (anecdotal)
Headache (uncommon)
GI discomfort

WADA Status

Not Prohibited (but testosterone itself is, if DAA raised testosterone beyond natural range, it could theoretically cause a failed test)

HOW AVELOR SCORES THIS

Products marketed as "testosterone boosters" with DAA as primary ingredient: flag, evidence does not support this claim in trained men

Fertility applications: more evidence; score accordingly

Any "test booster" proprietary blend: automatic flag

CLINICAL REFERENCES

Reference identifiers on this page are being re-verified against PubMed. Some may not yet link to the paper named beside them.

, Topo E et al. The role and molecular mechanism of D-aspartic acid in the release of LH and testosterone.

PMID: 19860889

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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