Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Coenzyme Q10

SupplementLast updated August 24, 2026

AVELOR SUMMARY

CoQ10 is a molecule your mitochondria use to produce cellular energy, and it also acts as an antioxidant. The evidence summarized here comes from 13 sources verified against their PubMed records: one large 2-year randomized controlled trial in chronic heart failure, one 12-year follow-up of a randomized trial, and 11 systematic reviews and meta-analyses. Across those sources, CoQ10 supplementation is associated with lower systolic blood pressure in cardiometabolic populations and with lower fatigue scores. Results for statin-associated muscle symptoms, migraine, and depressive symptoms conflict between review pools, and both sides are shown below. Statin users are a frequently studied group, because statin-associated muscle symptoms have been linked to mitochondrial dysfunction and micronutrient depletion.

EVIDENCE GRADES

Systolic blood pressure (cardiometabolic populations)

Moderate evidenceGrade B

Chronic heart failure

Moderate evidenceGrade B

Fatigue

Moderate evidenceGrade B

Statin-associated muscle symptoms

Limited evidenceGrade C

Migraine frequency

Limited evidenceGrade C

Depressive symptoms

Limited evidenceGrade C

Scan a supplement containing Coenzyme Q10

SAFETY PROFILE

Adverse Events Reported In The Cited Studies

The fatigue meta-analysis recorded a single gastrointestinal adverse event among 602 participants taking CoQ10 (Tsai 2022, PMID: 36091835).
The 33-trial heart failure pool reported the observed benefits occurred without major adverse effects (Xu 2024, PMID: 39462324).
The 2-year heart failure RCT concluded that long-term CoQ10 treatment in this population was safe (Mortensen 2014, PMID: 25282031).
The Cochrane review noted that in one of its three trials reporting adverse effects, CoQ10 was well tolerated (Ho 2016, PMID: 26935713).
Mild gastrointestinal complaints are the tolerability issue most often described. None of the sources cited here establishes a toxicity threshold, so this file makes no claim that toxicity has never occurred.

Drug Interactions

These interaction entries are pharmacologic cautions, not findings from the 13 sources cited above, except the blood pressure row. Evidence strength is labeled in each row.

Precautions

Pregnancy: Caution. None of the sources cited here studied supplementation in pregnancy.
Breastfeeding: Caution. None of the sources cited here studied supplementation while breastfeeding.
General: Anyone on statins, anticoagulants, or blood-pressure-lowering medication should discuss CoQ10 with their prescriber before starting.

WADA Status

Not Prohibited.

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

Present at 100-200mg:✅ Green flag, well-studied dose range with a real trial base

Underdosed (<50mg):⚠️ Yellow flag, below the range used in the cited trials

In a product for statin users without CoQ10:⚠️ Yellow flag, statin users are the most studied CoQ10 population even though the pools conflict

Combined with blood thinners:⚠️ Yellow flag, monitor INR

RELATED RESEARCH

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Scan Your Coenzyme Q10 Supplement Browse all ingredients

Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: August 24, 2026

Not medical advice. Based on published clinical research and systematic reviews.

Medication review

This source review is incomplete. It does not establish which combinations are safe or appropriate for you.

Warfarin

Source review required

The evidence is limited and conflicting. It does not establish a severity grade, a uniform effect, a warfarin dose change or equivalence with ubiquinol.

CoQ10 may affect warfarin response. A case report described reduced responsiveness, while a small four-week crossover trial found stable INR and no change in mean warfarin dose. These findings do not establish the same effect for every dose, preparation or patient.

If you take warfarin, discuss starting or stopping CoQ10 with your prescriber, including whether INR monitoring should change.

Prescriber discussion of starting or stopping CoQ10 and whether monitoring should change; no target INR, schedule or warfarin dose instruction.

Coenzyme Q10
Official source snapshot reviewed; this does not establish all claims in this entry.
[Interaction between warfarin and coenzyme Q10].
Original PubMed abstract/metadata inspected in the prior pinned packet; complete report not claimed unless explicitly stated.
[Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial].
Original PubMed abstract/metadata inspected in the prior pinned packet; complete report not claimed unless explicitly stated.

Blood pressure medications

Source review required

The reviewed sources do not establish interaction risks or benefits for the named blood-pressure medicines. They do not support medicine dose reduction, CoQ10 repletion instructions or a compatibility grade.

This limited review does not establish interaction risks between CoQ10 and blood-pressure medicines.

The reviewed source does not assess individual blood-pressure medicines or reduced-form CoQ10 (ubiquinol). It does not establish medicine dose reduction or a compatibility rating.

Chemotherapy

Source review required

Individual cancer-treatment regimens and supplement formulations have not been assessed. The official source does not establish a universal effect or the proposed cancer-cell protection mechanism.

NCCIH notes that CoQ10 may be incompatible with some cancer treatments. This review has not assessed individual treatment regimens.

Discuss CoQ10 use with the oncology team before combining it with cancer treatment.

Discussion with the oncology team; no instruction to change cancer treatment.

Coenzyme Q10
Official source snapshot reviewed; this does not establish all claims in this entry.

Insulin and diabetes medications

Source review required

The official caution concerns insulin. Other diabetes medicines remain unassessed. No insulin-sensitivity benefit or hypoglycemia frequency is established.

NCCIH lists a possible interaction between CoQ10 and insulin. This review does not establish its likelihood, dose relationship or applicability to other diabetes medicines.

Discuss combined use with the clinician who prescribes your insulin.

The source names insulin. It does not establish an interaction risk or benefit for metformin or other diabetes medicines.

Coenzyme Q10
Official source snapshot reviewed; this does not establish all claims in this entry.

Other combinations awaiting review (26)

Coenzyme Q10 with Warfarin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 supplementation with Warfarin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Nebivolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Bisoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Labetalol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Carvedilol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Ramipril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Losartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Enalapril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Ramipril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Losartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Valsartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Telmisartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Lisinopril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Atenolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Carvedilol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Nebivolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Bisoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Labetalol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Metoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Propranolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Atenolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Metoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Propranolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Metformin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Metformin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.

Discover More

Helps With

Heart Cholesterol Energy Fatigue Athletic Performance

Related Ingredients

Omega-3 Magnesium Vitamin E

Explore

Browse All 772 Ingredients Browse All 20 Conditions

Ingredient Research

Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Coenzyme Q10

SupplementLast updated August 24, 2026

AVELOR SUMMARY

EVIDENCE GRADES

Systolic blood pressure (cardiometabolic populations)

Moderate evidenceGrade B

Chronic heart failure

Moderate evidenceGrade B

Fatigue

Moderate evidenceGrade B

Statin-associated muscle symptoms

Limited evidenceGrade C

Migraine frequency

Limited evidenceGrade C

Depressive symptoms

Limited evidenceGrade C

Scan a supplement containing Coenzyme Q10

SAFETY PROFILE

Adverse Events Reported In The Cited Studies

The fatigue meta-analysis recorded a single gastrointestinal adverse event among 602 participants taking CoQ10 (Tsai 2022, PMID: 36091835).
The 33-trial heart failure pool reported the observed benefits occurred without major adverse effects (Xu 2024, PMID: 39462324).
The 2-year heart failure RCT concluded that long-term CoQ10 treatment in this population was safe (Mortensen 2014, PMID: 25282031).
The Cochrane review noted that in one of its three trials reporting adverse effects, CoQ10 was well tolerated (Ho 2016, PMID: 26935713).
Mild gastrointestinal complaints are the tolerability issue most often described. None of the sources cited here establishes a toxicity threshold, so this file makes no claim that toxicity has never occurred.

Drug Interactions

These interaction entries are pharmacologic cautions, not findings from the 13 sources cited above, except the blood pressure row. Evidence strength is labeled in each row.

Precautions

Pregnancy: Caution. None of the sources cited here studied supplementation in pregnancy.
Breastfeeding: Caution. None of the sources cited here studied supplementation while breastfeeding.
General: Anyone on statins, anticoagulants, or blood-pressure-lowering medication should discuss CoQ10 with their prescriber before starting.

WADA Status

Not Prohibited.

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

Present at 100-200mg:✅ Green flag, well-studied dose range with a real trial base

Underdosed (<50mg):⚠️ Yellow flag, below the range used in the cited trials

In a product for statin users without CoQ10:⚠️ Yellow flag, statin users are the most studied CoQ10 population even though the pools conflict

Combined with blood thinners:⚠️ Yellow flag, monitor INR

RELATED RESEARCH

Acacia Fiber

AcarboseANIMAL ONLY. In the NIA Interventions Testing Program, a parallel three-site study in genetically he

Activated Charcoal

Agave Inulin

Scan Your Coenzyme Q10 Supplement Browse all ingredients

Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: August 24, 2026

Not medical advice. Based on published clinical research and systematic reviews.

Medication review

This source review is incomplete. It does not establish which combinations are safe or appropriate for you.

Warfarin

Source review required

The evidence is limited and conflicting. It does not establish a severity grade, a uniform effect, a warfarin dose change or equivalence with ubiquinol.

If you take warfarin, discuss starting or stopping CoQ10 with your prescriber, including whether INR monitoring should change.

Prescriber discussion of starting or stopping CoQ10 and whether monitoring should change; no target INR, schedule or warfarin dose instruction.

Coenzyme Q10
Official source snapshot reviewed; this does not establish all claims in this entry.
[Interaction between warfarin and coenzyme Q10].
Original PubMed abstract/metadata inspected in the prior pinned packet; complete report not claimed unless explicitly stated.
[Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial].
Original PubMed abstract/metadata inspected in the prior pinned packet; complete report not claimed unless explicitly stated.

Blood pressure medications

Source review required

This limited review does not establish interaction risks between CoQ10 and blood-pressure medicines.

The reviewed source does not assess individual blood-pressure medicines or reduced-form CoQ10 (ubiquinol). It does not establish medicine dose reduction or a compatibility rating.

Chemotherapy

Source review required

Individual cancer-treatment regimens and supplement formulations have not been assessed. The official source does not establish a universal effect or the proposed cancer-cell protection mechanism.

NCCIH notes that CoQ10 may be incompatible with some cancer treatments. This review has not assessed individual treatment regimens.

Discuss CoQ10 use with the oncology team before combining it with cancer treatment.

Discussion with the oncology team; no instruction to change cancer treatment.

Coenzyme Q10
Official source snapshot reviewed; this does not establish all claims in this entry.

Insulin and diabetes medications

Source review required

The official caution concerns insulin. Other diabetes medicines remain unassessed. No insulin-sensitivity benefit or hypoglycemia frequency is established.

NCCIH lists a possible interaction between CoQ10 and insulin. This review does not establish its likelihood, dose relationship or applicability to other diabetes medicines.

Discuss combined use with the clinician who prescribes your insulin.

The source names insulin. It does not establish an interaction risk or benefit for metformin or other diabetes medicines.

Coenzyme Q10
Official source snapshot reviewed; this does not establish all claims in this entry.

Other combinations awaiting review (26)

Coenzyme Q10 with Warfarin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 supplementation with Warfarin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Nebivolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Bisoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Labetalol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Carvedilol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Ramipril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Losartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Enalapril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Ramipril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Losartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Valsartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
CoQ10 with Telmisartan
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Lisinopril
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Atenolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Carvedilol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Nebivolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Bisoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Labetalol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Metoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Propranolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Atenolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Metoprolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Propranolol
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Ubiquinol (reduced CoQ10) with Metformin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.
Coenzyme Q10 with Metformin
Source review required
The risk, benefit, preparation and dose context for this recorded combination remain under review. This entry does not establish that the combination is safe.

Discover More

Helps With

Heart Cholesterol Energy Fatigue Athletic Performance

Related Ingredients

Omega-3 Magnesium Vitamin E

Explore

Browse All 772 Ingredients Browse All 20 Conditions

Coenzyme Q10

AVELOR SUMMARY

EVIDENCE GRADES

SAFETY PROFILE

Adverse Events Reported In The Cited Studies

Drug Interactions

Precautions

WADA Status

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

RELATED RESEARCH

Medication review

Warfarin

Blood pressure medications

Chemotherapy

Insulin and diabetes medications

Coenzyme Q10 with Warfarin

Coenzyme Q10 supplementation with Warfarin

Coenzyme Q10 with Nebivolol

Coenzyme Q10 with Bisoprolol

Coenzyme Q10 with Labetalol

Coenzyme Q10 with Carvedilol

Ubiquinol (reduced CoQ10) with Ramipril

Ubiquinol (reduced CoQ10) with Losartan

CoQ10 with Enalapril

CoQ10 with Ramipril

CoQ10 with Losartan

CoQ10 with Valsartan

CoQ10 with Telmisartan

Ubiquinol (reduced CoQ10) with Lisinopril

Ubiquinol (reduced CoQ10) with Atenolol

Ubiquinol (reduced CoQ10) with Carvedilol

Ubiquinol (reduced CoQ10) with Nebivolol

Ubiquinol (reduced CoQ10) with Bisoprolol

Ubiquinol (reduced CoQ10) with Labetalol

Ubiquinol (reduced CoQ10) with Metoprolol

Ubiquinol (reduced CoQ10) with Propranolol

Coenzyme Q10 with Atenolol

Coenzyme Q10 with Metoprolol

Coenzyme Q10 with Propranolol

Ubiquinol (reduced CoQ10) with Metformin

Coenzyme Q10 with Metformin

Discover More

Coenzyme Q10

AVELOR SUMMARY

EVIDENCE GRADES

SAFETY PROFILE

Adverse Events Reported In The Cited Studies

Drug Interactions

Precautions

WADA Status

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

RELATED RESEARCH

Medication review

Warfarin

Blood pressure medications

Chemotherapy

Insulin and diabetes medications

Coenzyme Q10 with Warfarin

Coenzyme Q10 supplementation with Warfarin

Coenzyme Q10 with Nebivolol

Coenzyme Q10 with Bisoprolol

Coenzyme Q10 with Labetalol

Coenzyme Q10 with Carvedilol

Ubiquinol (reduced CoQ10) with Ramipril

Ubiquinol (reduced CoQ10) with Losartan

CoQ10 with Enalapril

CoQ10 with Ramipril

CoQ10 with Losartan

CoQ10 with Valsartan

CoQ10 with Telmisartan

Ubiquinol (reduced CoQ10) with Lisinopril

Ubiquinol (reduced CoQ10) with Atenolol

Ubiquinol (reduced CoQ10) with Carvedilol

Ubiquinol (reduced CoQ10) with Nebivolol

Ubiquinol (reduced CoQ10) with Bisoprolol

Ubiquinol (reduced CoQ10) with Labetalol

Ubiquinol (reduced CoQ10) with Metoprolol

Ubiquinol (reduced CoQ10) with Propranolol