What is the recommended dose of Butyrate / Butyric Acid?

- **Look for:** Tributyrin (ProButyrate®, best delivery to colon); sodium butyrate; calcium/magnesium butyrate; enteric-coated or delayed-release; 300-600mg per serving - **Avoid:** Plain butyric a...

Is Butyrate / Butyric Acid safe to take daily?

Butyrate / Butyric Acid is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

LOADINGLoading your Pro surface...

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Butyrate / Butyric Acid

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Butyrate is the most important short-chain fatty acid (SCFA) for gut health, it's the PRIMARY energy source for colonocytes (cells lining your colon get 70% of their energy from butyrate, not glucose). Your gut bacteria produce it by fermenting dietary fiber. Our research shows butyrate has profound effects: it maintains intestinal barrier integrity (prevents "leaky gut"), has anti-cancer effects in colorectal tissue (paradoxically, it feeds normal colonocytes but kills cancer cells via the "butyrate paradox"), reduces inflammation via HDAC inhibition, and has emerging evidence for brain function via the gut-brain axis. Supplemental butyrate (as sodium/calcium butyrate or tributyrin) can bypass the need for fiber fermentation.

WHAT IT DOES

Butyrate's mechanisms: (1) Colonocyte fuel, enters mitochondria via β-oxidation, providing 70% of colonocyte ATP (healthy colonocytes preferentially use butyrate over glucose); (2) HDAC inhibition, butyrate is a class I/II histone deacetylase inhibitor, altering gene expression toward anti-inflammatory, anti-proliferative, and pro-apoptotic programs (this is the anti-cancer mechanism); (3) GPR41/GPR43/GPR109A receptor activation, these SCFA receptors on immune cells, enteroendocrine cells, and neurons mediate immune tolerance (Treg induction), GLP-1/PYY secretion (satiety), and gut-brain signaling; (4) tight junction protein upregulation, increases expression of claudins and occludin, strengthening the intestinal barrier; (5) mucosal blood flow increase, vasodilatory effects in colonic vasculature.

OPTIMAL DOSAGE

Look for: Tributyrin (ProButyrate®, best delivery to colon); sodium butyrate; calcium/magnesium butyrate; enteric-coated or delayed-release; 300-600mg per serving
Avoid: Plain butyric acid liquid (rancid smell, gastric irritation); products without delayed-release (butyrate absorbed in small intestine before reaching colon)
Minimum effective dose: 300mg 2x/day supplemental butyrate
Third-party tested brands: BodyBio (sodium butyrate), Designs for Health (Tributyrate-X), NOW Foods

Scan a supplement containing Butyrate / Butyric Acid

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

WHO SHOULD BE CAREFUL

RELATED RESEARCH

Acacia Fiber

AcarboseANIMAL ONLY. In the NIA Interventions Testing Program, a parallel three-site study in genetically he

Activated Charcoal

Agave Inulin

Scan Your Butyrate / Butyric Acid Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions