What is the recommended dose of Bromelain?

- **Anti-inflammatory:** 500-2,000mg/day in divided doses - **Post-surgical:** 500mg 3x/day starting 3 days before surgery - **Sinusitis:** 500-1,000mg/day - Measured in GDU (gelatin dissolving uni...

Is Bromelain safe to take daily?

Bromelain is rated "Prescription Interactions" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Does Bromelain interact with any medications?

Bromelain has 4 known drug interactions, including interactions with Anticoagulants (warfarin, heparin), Aspirin, Antibiotics (amoxicillin, tetracycline). Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Bromelain

MODERATE EVIDENCESupplementLast updated April 2026

AVELOR SUMMARY

Bromelain is a proteolytic enzyme complex from pineapple stems with evidence for surgical swelling/bruising reduction, sinusitis, and osteoarthritis pain. Our research identifies it as a legitimate anti-inflammatory enzyme, but bioavailability is low and it interacts significantly with blood thinners.

EVIDENCE GRADES

Post-surgical swelling/bruisingModerate, multiple surgical trials (PMID: 11185341)

Sinusitis (adjunct)Moderate, improves mucociliary clearance

B-

OsteoarthritisLimited trials

C+

Muscle soreness (DOMS)Preliminary

Digestive supportTraditional use; limited clinical data

OPTIMAL DOSAGE

Anti-inflammatory: 500-2,000mg/day in divided doses
Post-surgical: 500mg 3x/day starting 3 days before surgery
Sinusitis: 500-1,000mg/day
Measured in GDU (gelatin dissolving units), higher GDU = more enzymatic activity
Take on empty stomach for systemic effects; with food for digestive support

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DRUG INTERACTIONS

Anticoagulants (warfarin, heparin)Severe

Bromelain has antiplatelet/fibrinolytic activity, additive bleeding risk

AspirinModerate

Additive antiplatelet effects

Antibiotics (amoxicillin, tetracycline)Moderate

Bromelain may increase antibiotic tissue levels

SedativesMinor

May potentiate sedative effects

SAFETY PROFILE

Drug Interactions

Pregnancy & Lactation

Insufficient data. May stimulate uterine contractions at high doses. Avoid.

WADA Status

Not Prohibited

CLINICAL REFERENCES

Reference identifiers on this page are being re-verified against PubMed. Some may not yet link to the paper named beside them.

, Maurer HR. Bromelain: biochemistry, pharmacology and medical use.

PMID: 11185341

, Brien S et al. Bromelain as treatment for osteoarthritis.

PMID: 16304621

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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