Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD
Alpha-Ketoglutarate
MODERATE EVIDENCESupplementLast updated
AVELOR SUMMARY
AKG is a TCA cycle intermediate and longevity compound. Ca-AKG extended mouse lifespan by 12% and reduced frailty (Ames 2021). AKG levels decline 10x from age 40 to 60 in humans. Also enhances collagen synthesis (proline precursor), improves exercise performance (TCA cycle fuel), and may lower biological age (TruAge epigenetic clock reduction in human pilot). Dose: 1-2g/day calcium-AKG.
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*Reviewed by the Dose AI Research Team and Clinical Advisory Board*
*Last updated: 2026-04-06*
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.