What is the recommended dose of Alpha-GPC?

- **For cognitive decline/dementia:** 1,200mg/day (400mg 3x/day) - **For exercise performance:** 300-600mg, 30-60 minutes before exercise - **Timing:** Divided doses. Pre-workout for performance.

Does Alpha-GPC interact with any medications?

Alpha-GPC lists 1 reported drug interaction whose sources are not yet verified, including interactions with Anticholinergic drugs (scopolamine, diphenhydramine, etc.). Check with your doctor before combining with prescription medications.

Ingredient Research

Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Alpha-GPC

SupplementLast updated April 5, 2026

AVELOR SUMMARY

Alpha-GPC is a choline compound that crosses the blood-brain barrier and boosts acetylcholine, the neurotransmitter critical for memory and learning. Our research, from 5 RCTs and 390 participants, shows moderate evidence for cognitive improvement (especially in dementia) and power output enhancement. However, there's a concerning signal: observational data links alpha-GPC supplementation to increased cardiovascular disease and stroke risk through TMAO production. This is still preliminary, but it's worth flagging.

EVIDENCE GRADES

Cognition (dementia patients)

Moderate evidenceGrade B

Dementia Symptoms

Moderate evidenceGrade B

Growth Hormonesmall increase

Moderate evidenceGrade B

Power Output

Moderate evidenceGrade B

OPTIMAL DOSAGE

For cognitive decline/dementia: 1,200mg/day (400mg 3x/day)
For exercise performance: 300-600mg, 30-60 minutes before exercise
Timing: Divided doses. Pre-workout for performance.

Scan a supplement containing Alpha-GPC

DRUG INTERACTIONS

Anticholinergic drugs (scopolamine, diphenhydramine, etc.)

Counteracts drug effect

Be aware of opposing mechanisms.

SAFETY PROFILE

Side Effects

Common: Heartburn, nausea, vomiting, headache, insomnia, restlessness, constipation
Potential concern: May increase TMAO (trimethylamine-N-oxide), which is associated with cardiovascular disease. Observational study found dose-dependent stroke risk increase over 10 years.

Precautions

Pregnancy/Breastfeeding: Caution. Metabolized to choline (essential nutrient), so likely safe. Not specifically studied in pregnancy.
Cardiovascular disease risk: Emerging concern. Alpha-GPC promotes TMAO and may increase atherosclerosis and stroke risk. More research needed.

WADA Status

Not Prohibited.

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

Present at 300-1,200mg:✅ Green flag with ⚠️ CVD caveat, effective nootropic but emerging cardiovascular concerns

Underdosed (<200mg):⚠️ Yellow flag, below studied effective range

In someone with cardiovascular disease:⚠️ Yellow flag, TMAO association warrants caution

RELATED RESEARCH

Acacia Fiber

AcarboseANIMAL ONLY. In the NIA Interventions Testing Program, a parallel three-site study in genetically he

Activated Charcoal

Agave Inulin

Scan Your Alpha-GPC Supplement Browse all ingredients

Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 5, 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 772 Ingredients Browse All 20 Conditions

Ingredient Research

Graded against 178,763 supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Alpha-GPC

SupplementLast updated April 5, 2026

AVELOR SUMMARY

EVIDENCE GRADES

Cognition (dementia patients)

Moderate evidenceGrade B

Dementia Symptoms

Moderate evidenceGrade B

Growth Hormonesmall increase

Moderate evidenceGrade B

Power Output

Moderate evidenceGrade B

OPTIMAL DOSAGE

For cognitive decline/dementia: 1,200mg/day (400mg 3x/day)
For exercise performance: 300-600mg, 30-60 minutes before exercise
Timing: Divided doses. Pre-workout for performance.

Scan a supplement containing Alpha-GPC

DRUG INTERACTIONS

Anticholinergic drugs (scopolamine, diphenhydramine, etc.)

Counteracts drug effect

Be aware of opposing mechanisms.

SAFETY PROFILE

Side Effects

Common: Heartburn, nausea, vomiting, headache, insomnia, restlessness, constipation
Potential concern: May increase TMAO (trimethylamine-N-oxide), which is associated with cardiovascular disease. Observational study found dose-dependent stroke risk increase over 10 years.

Precautions

Pregnancy/Breastfeeding: Caution. Metabolized to choline (essential nutrient), so likely safe. Not specifically studied in pregnancy.
Cardiovascular disease risk: Emerging concern. Alpha-GPC promotes TMAO and may increase atherosclerosis and stroke risk. More research needed.

WADA Status

Not Prohibited.

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

Present at 300-1,200mg:✅ Green flag with ⚠️ CVD caveat, effective nootropic but emerging cardiovascular concerns

Underdosed (<200mg):⚠️ Yellow flag, below studied effective range

In someone with cardiovascular disease:⚠️ Yellow flag, TMAO association warrants caution

RELATED RESEARCH

Acacia Fiber

AcarboseANIMAL ONLY. In the NIA Interventions Testing Program, a parallel three-site study in genetically he

Activated Charcoal

Agave Inulin

Scan Your Alpha-GPC Supplement Browse all ingredients

Independently graded against 178,763 indexed supplements and 757 reviewed supplement and medication pairs, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 5, 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 772 Ingredients Browse All 20 Conditions