What works, what does not, and what is dangerous. Reviewed by theAvelor Research Team.
Effective Dose
200mg silymarin twice daily
Reduced hot flash frequency and severity (~68% severity drop) in one quality RCT.
PMID: 27624881Effective Dose
50-80mg daily
Modest reduction in hot flash frequency. Effect varies by equol-producer status.
PMID: 22433977Effective Dose
1000-2000 IU/day
Critical for bone health and calcium absorption. Test and target 40-60 ng/mL.
PMID: 28359097Effective Dose
1000-1200mg total daily (diet + supplement)
Bone density protection. Food sources preferred — supplements linked to mild cardiovascular signals.
PMID: 20717045Effective Dose
200-400mg
Improves sleep quality and may reduce muscle cramps common in menopause.
PMID: 23853635Effective Dose
1-2g daily
Supports cardiovascular and cognitive health during the post-menopausal cardiovascular risk shift.
PMID: 18029469Evening Primrose Oil
Multiple RCTs show no benefit for hot flashes.
Wild Yam Cream
Contains diosgenin but the body does NOT convert it to progesterone. Marketing claim is biologically false.
DIM (Diindolylmethane)
Popular for "hormone balance" but trial evidence is thin.
Generic "Menopause Support" Blends
Typically combine underdosed soy, black cohosh, and evening primrose with marketing copy.
Reports of hepatitis. Monitor liver function if used.
Phytoestrogen activity may interfere.
CYP3A4 induction reduces drug effectiveness.
Increased bleeding risk.