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What works, what does not, and what is dangerous. Reviewed by theAvelor Research Team.
Effective Dose
Full formula daily
25% reduction in progression of intermediate to advanced AMD. Lutein+zeaxanthin replaced beta-carotene.
PMID: 23644932Effective Dose
10mg lutein + 2mg zeaxanthin daily
Core carotenoids in AREDS2. Concentrate in the macula.
PMID: 23644932Effective Dose
25-80mg elemental zinc with copper
AREDS2 component. Long-term high-dose zinc requires copper to prevent deficiency.
PMID: 23644932Effective Dose
500-1000mg DHA
Supports retinal photoreceptor membranes. Did NOT slow AMD in AREDS2 but remains foundational for eye tissue health.
PMID: 23644932Effective Dose
500mg C + 400 IU E
AREDS2 antioxidants. Less critical than lutein/zeaxanthin/zinc but part of the complete formula.
PMID: 23644932Original AREDS with Beta-Carotene
Raised lung cancer risk in smokers and former smokers. AREDS2 replaced it — use that instead.
Bilberry for Night Vision
WWII pilot myth. No credible RCT support for night vision in modern studies.
Fish Oil for AMD
Did not slow AMD progression in the AREDS2 trial when added to the formula.
Generic "Eye Health" Blends
Under-dose lutein/zeaxanthin vs the AREDS2 target. Check the label against AREDS2 spec.
Increased lung cancer risk — original AREDS pulled for this reason.
Zinc-induced copper deficiency. Use AREDS2 version with copper included.
Theoretical bleeding risk at high doses.
Hepatotoxicity and, in pregnancy, teratogenicity above 10,000 IU.