What works, what does not, and what is dangerous. Reviewed by theAvelor Research Team.
Effective Dose
4g MI + 100mg DCI (40:1 ratio) daily
Strongest supplement evidence in PCOS. Restores ovulation, reduces insulin resistance.
PMID: 27808588Effective Dose
1200-1800mg/day
Improved ovulation and pregnancy rates when combined with clomiphene in PCOS.
PMID: 25707012Effective Dose
2000-4000 IU/day to 40-60 ng/mL
Common deficiency in PCOS. Improves insulin sensitivity when replete.
PMID: 28359097Effective Dose
500mg 3x/day with meals
Comparable to metformin for insulin resistance and androgen reduction. Use under medical supervision.
PMID: 22961660Effective Dose
2 cups daily
Small trials show mild androgen reduction and hirsutism improvement.
PMID: 19585478Effective Dose
1-2g daily
Reduces triglycerides and supports metabolic profile in PCOS.
PMID: 28165108Chromium Picolinate
Small, inconsistent effect in PCOS. Not worth centering a protocol around.
DIM (Diindolylmethane)
Popular for androgen support but evidence in PCOS is thin.
Generic "PCOS Blends"
Often combine inositol at sub-therapeutic doses with filler botanicals. Buy inositol standalone.
Licorice Root
Androgen-lowering effect is real but so are blood pressure spikes. Avoid.
Hypoglycemia, CYP interactions, QT prolongation in predisposed individuals.
Hypertension, hypokalemia, cardiac issues at regular doses.
Theoretical hormonal interference.
Potentiated vasodilation.