What works, what does not, and what is dangerous. Reviewed by theAvelor Research Team.
Effective Dose
500-2000mg with piperine or phytosome
Reduces CRP, IL-6, TNF-alpha over 8-12 weeks. Must use enhanced absorption form.
PMID: 27633135Effective Dose
2-4g EPA+DHA/day
Reduces triglycerides and inflammatory markers. Look for IFOS 5-star certified brands.
PMID: 21939553Effective Dose
100-250mg standardized AKBA
Faster-acting than curcumin. Useful for osteoarthritis and gut inflammation.
PMID: 22622131Effective Dose
1-2g DHA+EPA
Plant-based alternative to fish oil with comparable triglyceride effect.
PMID: 25972428Effective Dose
500-2000mg standardized
Modest anti-inflammatory effect for osteoarthritis pain and menstrual pain.
PMID: 11710709SPMs (Pro-Resolving Mediators)
Biological story is compelling but human RCTs are thin. Premium pricing is not earned.
Plain Curcumin (no enhancer)
Curcumin has terrible oral bioavailability. Without BioPerine or phytosome, little reaches your bloodstream.
Krill Oil (for inflammation)
Comparable to fish oil at 3-5x the price. No unique anti-inflammatory advantage proven.
Generic "Inflammation" Blends
Usually under-dose curcumin and omega-3. Buy each component separately.
Increased bleeding risk. Keep <3g/day unless cleared by prescriber.
Additive bleeding risk.
Theoretical immune-modulating effect. Check with prescriber.
Additive antiplatelet effect.