What works, what does not, and what is dangerous. Reviewed by theAvelor Research Team.
Effective Dose
1.6-2.2g/kg/day total
Prevents lean mass loss during GLP-1-induced weight loss. Most GLP-1 users undereat protein.
PMID: 28698222Effective Dose
1000mcg methylcobalamin
GLP-1 users often skip meals, reducing B12 intake. Test if fatigued.
PMID: 23356638Effective Dose
1000-4000 IU/day
Rapid weight loss + lower food intake = lower vitamin D. Test and supplement to 40-60 ng/mL.
PMID: 28359097Effective Dose
1-2g/day
Supports cardiovascular and cognitive health during calorie restriction.
PMID: 29145952Effective Dose
Sodium 1-2g, potassium 500-1000mg, magnesium 300-400mg
GLP-1 reduces food (and electrolyte) intake. Helps with fatigue, cramps, constipation.
PMID: 23829965Effective Dose
3-5g daily
Preserves muscle and strength during aggressive weight loss.
PMID: 28615987Effective Dose
200-400mg
Counters constipation and cramping common in early GLP-1 use.
PMID: 28445426Topical GLP-1 Patches
Peptides of this size cannot absorb transdermally. 100% marketing, zero pharmacology.
"Nature's Ozempic" Berberine Blends
Berberine has a small metabolic effect but does not produce GLP-1-class weight loss.
Gymnema Sylvestre
Minimal evidence for weight loss. Immune reactions reported.
Compounded tirzepatide+B12
Independent testing found ~43% of labeled potency with unknown impurities. Use FDA-approved products.
Apple Cider Vinegar for Weight Loss
Key study retracted. Negligible effect on weight in credible trials.
Compounded GI side effects, hypoglycemia risk.
Unpredictable additive blood sugar drop.
Slowed gastric emptying compounds. Severe constipation or obstruction risk.
Hypoglycemia risk in aggressive stacking.